Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation
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چکیده
منابع مشابه
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation.
Tolerance to opioid administration represents a serious medical alert in different chronic conditions. This study compares the effects of the imidazoline compounds 1, 2, and 3 on morphine tolerance in an animal model of inflammatory pain in the rat. 1, 2, and 3 have been selected in that, although bearing a common scaffold, preferentially bind to α2-adrenoceptors, imidazoline I2 receptors, or b...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2015
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2015.11.021